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Lipo-B (MIC) Injection
Methionine Inositol Choline (MIC) Injections, also referred to as Lipo Injections, are used to help release fat throughout the body by specifically targeting its primary fatty deposits. Lipotropics or fat burning substances include; inositol, which helps the liver remove fat; choline, which distributes cholesterol and prevents it from getting deposited in one part of the body; and methionine, which is similar to inositol but also amplifies the combination. Injections can be administered up to twice a week, and vitamin B-12 is purported by practitioners and users to help accelerate metabolic processes all while creating a greater feeling of overall energy. Since lipotropic’s directly aid in the breakdown of fatty tissues and are also closely related to B vitamins, when used together, they are thought to intensify each others’ effects and are usually injected together as part of the same treatment injection cycle.
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What is this medicine used for? Lipotropic injections are used to help release fat deposits in some parts of the body. Some of these areas include the stomach, inner thighs, neck, buttocks, and hips. Lipotropic, or fat burning, substances include methionine which helps the liver remove fat; inositol, similar to methionine; choline, which distributes cholesterol and prevents it from getting deposited in one part of the body. In some cases, a combination of these may be given. Injections can be administered up to twice a week. B12 is purported by its users and practitioners to help speed up the overall metabolic processes and create a greater feeling of overall energy. Because lipotropics directly aid fat breakdown and are closely related to B vitamins, when used together they are thought to intensify each others’ effects. They are usually injected separately but as part of the same overall injection cycle. The amino acids that are injected into the body stimulate the liver into optimizing the process of metabolism. These injections boost the metabolic power of the body. .
Lipo-B Injection is commonly prescribed for:
Help stimulate the breakdown of lipids (fat) during metabolism
To reduce the accumulation of excess fat in the liver and other tissues
Lipo-B is a mixture of compounds that may aid in the reduction of adipose tissue (fat). The mixture of compounds individually may be effective, however, in combination, they may exhibit more lipotropic activity than when administered alone in a synergistic fashion. Injection of this mixture of lipotropic compounds may be more effective than oral supplementation, this is due to the increased bioavailability of parenteral exposure.
These lipotropic agents are structurally and functionally closely related to the B-vitamins, or are involved in the homeostasis of energy production from fat. These compounds are often employed together in the hope of potentiating fat-loss, thus while the MIC mixture and B vitamin(s) are often injected separately, they are part of the same overall injection cycle. The non-vitamin compounds (MIC) that are injected into the body stimulate the liver into optimizing the process of metabolism, elevate the movement of and utilization of fat, and provide the needed metabolic environment of the body for a fatty acid (fat) mobilization and utilization.
Typically, these compounds are administered in concert. Injections can be administered up to twice a week.
Lipotropic compounds are used to increase the potential for release of fat deposits in some parts of the body. The lipotropic agents included in this injection are:
Methionine helps the liver maintain the optimal ability to process fatty acids 1. Methionine is a major constituent of S-adenosylmethionine which has been shown to be associated in genetic regulation and activation of certain genes 2. Methionine contributes to methyl donation to histones that activate certain genetic processes that may be involved in the increase in lean tissue. Although indirectly linked to lipolysis, it is believed that the increase in lean tissue increases resting metabolic rate, therefore increasing the overall required calories that must be obtained from storage or dietary intake. Methionine, via S-adenosylmethionine, has been shown in animal models to increase CNS activity, therefore increasing the caloric requirements required by the CNS3. The downstream effects of this may ultimately lead to increased caloric requirements for the entire organism. Although studies have not been replicated 4 in humans, there may be an association due to the similarity in pathways shared between organisms.
Inositol is a sugar-like molecule, referred to as a sugar alcohol. Even though very similar in molecular structure to glucose, this molecule does not exhibit the traits that simple carbohydrates exhibit. Contrary to simple carbohydrates, this sugar alcohol has been shown to not actively increase adipose storage. In fact, Inositol has been found to decrease fatty acid synthase activity, a multi-enzyme protein that catalyzes fatty acid synthesis. This set of enzymes ultimately enables the body to produce triglycerides fat molecules that reside in adipose tissue (body fat) 3.
Inositol may be effective in reducing insulin resistance, a common condition associated with increase adiposity (body fat) 5. Insulin resistance, a condition to which your body becomes resistant to the activities of the hormone insulin. This condition leads to excess blood glucose levels and a host of symptoms and dysfunctions. A chemical called Inositol phosphoglycan is known to regulate the body’s sensitivity to insulin signaling. Inositol phosphoglycan structurally incorporates Inositol, thus inositol is required for this molecule to exert its regulating behavior.
The proper functioning and sensitivity to insulin is found in most healthy individuals, and is essential in maintaining overall health. Excessive exposure to blood glucose ultimately leads to insulin resistance and poor nutrient transport. Inositol may be effective in reducing this condition while at the same time reducing fatty acid (fat) synthesis.
Choline is a simple molecule usually classified as a B vitamin. The B vitamin class is usually involved in the generation of energy and support of metabolism. Choline is an important precursor to the neurotransmitter acetylcholine. This neurotransmitter is involved in a host of activities, one of which includes muscular function and contraction. Acetylcholine is a fundamental neurotransmitter that enables the communication between neurons. Increased neural communication results in increased CNS activity which ultimately leads to increased energy expenditure. Energy expenditure requires nutrient input, either from stored energy (fat), or dietary nutrients. Choline exist in a delicate balance and homeostasis with methionine and folate. When these nutrients are not in balance adverse health effects may be present. Along with the increase in CNS activity comes increased cognitive ability, reported by many users. Choline may be effective as a nootropic, or a substance with ability to increase cognition. Increased neural cognition is thought to be due to choline’s role as a precursor to acetylcholine.
The supplementation of choline has been shown to reduce serum and urinary carnitine 4. The reduction of carnitine in these fluids may indicate carnitine has been partitioned in tissues that utilize it as a fatty acid mitochondrial transport. When carnitine is used in the mitochondria it transports fatty acids to the location which they are broken down and used as energy. It has also been reported that molecular fragments of fat have been found in urine after carnitine and choline supplementation, which may be due to incomplete fatty acid oxidation and the removal of the subsequent byproducts 4. This means, choline supplementation may increase the utilization of carnitine and increase the removal of fatty acids, even though all fatty acids are not burned as energy. The fragments of fatty acids not burned as energy are extruded in the urine as molecular fragments.
Cyanocobalamin is an essential nutrient known as vitamin B12. This version of B12 contains a functional cyano. Cyanocobalamin is a form of vitamin B12, it is the most widely used form of vitamin B12. The vitamin B12 is fundamental in many biological processes, many of which are important to the survival of the organism. Vitamin B12 is involved in processes including DNA synthesis, fatty acid and amino acid metabolism.
B12 is purported by its users and practitioners to help speed up overall metabolic processes and create a greater feeling of overall energy and well-being 6. Individuals may be deficient in vitamin B12, these individuals must supplement B12. Deficiency is present for a variety of reasons including dietary deficiency and poor dietary absorption. The human body is incapable of producing vitamin B12 on its own, B12 must be consumed in the diet. Consumption of vitamin B-12 may be an effective agent to speed up metabolism, especially if the individual has a deficiency.
Who should not take this medicine? If you have an allergy to methionine, inositol, choline, or any part of this medicine. Tell your healthcare provider if you are allergic to any medicine. This includes rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
What are the precautions when taking this medicine? You may experience injection site irritation. Be careful if you drive or do anything that requires you to be alert.
Key warnings before taking this medicine: This medication is to be injected intramuscularly.
How is it best taken? This medication is to be injected intramuscularly. DO NOT inject intravenously. This medicine can be taken at any time during the day. Follow diet plan and exercise program as recommended by health care provider.
What do I do if I miss a dose? If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Take your next regularly scheduled dose. Do not take two doses at the same time.
What are some possible side effects of this medicine? Potential side effects include stomach upset and urinary problems due to the strain the injections place on the kidneys. Depression is another possible side effect. Some patients are unable to control their urine, and/or have diarrhea. Finally, some patients reported an unpleasant odor. Lipotropic injections change the function of the digestive system temporarily. This can result in extreme exhaustion, since the body is not used to working at this level and condition. Unexplained pain in unrelated parts of the body is another potential side effect. Patients have complained of pain in the neck and parts of the hand. How these injections cause these pains is not clear. Some patients have also experienced joint pains and allergic reactions to the injections. Call your healthcare provider immediately if you are experiencing any signs of an allergic reaction: wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat; also if you experience severe behavioral problems, chest pain or pressure or fast heartbeat, severe dizziness or passing out, nervousness and excitability, or severe headache.
How should I store this medicine? Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the expiration date. Do not flush unused medications or pour down a sink or drain.
General statements: Do not share or take any one else’s medicine. Talk with your healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins. This medication was compounded specifically for you. This patient information summarizes the most important information about your medication; if you would like more information, talk with your doctor.
How MIC Injections Work
The amino acids that are injected into the body stimulate the liver into optimizing the process of metabolism. These injections boost the body’s metabolic power by providing a highly effective temporary increase of normal metabolic functions. As soon as the effect of these substances wears off, the body begins to gradually return to its normal metabolic rate. When administered in combination with a low-calorie diet and regular exercise, our lipotropic formulas can help your body to rid itself of fat, while simultaneously increasing your energy levels both via the fat released energy and the energy promoting properties of vitamin B-12. The formula used in the MIC Injection specially blends the following important ingredients:
Methionine – The “M” in MIC Injection, is an essential amino acid, which means that it is not synthesized in humans. This amino acid acts as a lipotropic agent which: assists in the breakdown of fats within the liver; helps to lower cholesterol thereby preventing excess fat buildup in the liver and throughout your body’s circulatory system; is helpful in preventing and relieving fatigue; and is useful in some cases of allergies by virtue of its ability to reduce histamine release.
One of the sulfur-containing amino acids (along with cysteine and cystine), methionine is important (essential) to many bodily functions and must be directly consumed through supplementation or methionine-containing proteins. Foods which contain high levels of methionine include cheese, eggs, fish, meats, spinach, potatoes, Brazil nuts, sesame seeds, and select other plant seeds. However, by injecting methionine into your muscles you can rapidly achieve high concentrations which many researchers and physicians believe results in more effective mobilization and elimination of abnormal fatty deposits. Other reported benefits of methionine include improvement of: liver disease; skin tone and elasticity; nails; hair; and cardiovascular and muscular functions, through its role in the production of creatine. It has also been used to treat premature ejaculation, chronic depression, pancreatitis, Parkinson’s disease, and AIDS myelopathy. More specifically, clinical research has clearly demonstrated methionine’s ability to “…strongly improve the alcohol-induced histological changes in the liver. Triglyceride content of the liver was found to decrease in a dose-dependent manner with increasing methionine ingestion.
Inositol – The “I” in MIC Injection, is a B-vitamin that promotes: the health of cell structures and nerve synapses; aids in the metabolism of fats; helps reduce blood cholesterol; and participates in the action of serotonin, a neurotransmitter known to control mood and appetite.
Also known as myo-inositol, inositol is best described as a carbocyclic polyol, which forms the basis for many signaling and secondary messenger molecules. As such, it is involved in many biological processes, including the breakdown of fats, the reduction of serum cholesterol, serotonin activity modulation, gene expression, and insulin signal transduction. It is not considered a vitamin because your body is unable to synthesize it. However, it has been shown to be helpful for the treatment of depression, panic disorder, polycystic ovarian syndrome, and fatty liver. It also important for optimal brain function.
Inositol deficiency may manifest as symptoms of constipation, high cholesterol, vision problems, and hair loss. Although it is naturally found in certain foods such as nuts, beans (especially red beans and kidney beans), grains, cantaloupe melons, and oranges, it is more effective in breaking down fat when given as an intramuscular injection.
Choline – The “C” in MIC Injection, is an essential nutrient that helps to support the liver in its processing and excretion of chemical waste products. Moreover, it is required for the transport and metabolism of fats and cholesterol, which is important for the healthy support of the endocrine, cardiovascular, and hepatic systems.
A few specific studies have clearly demonstrated:
“Choline supplementation normalized cholesterol metabolism, which was sufficient to prevent nonalcoholic steatohepatitis development and improve liver function. Our data suggest that choline can promote liver health by maintaining cholesterol homeostasis.”10
“Choline induces glucose and insulin intolerance in Pemt(-/-) mice through modulating plasma glucagon and its action in liver”.
Choline supplementation decreased the concentration of liver triacylglycerol during the first 4 wk after parturition. Results from this study suggest that hepatic fat export in periparturient dairy cows is improved by choline supplementation during the transition period and this may potentially decrease the risk for metabolic disorders in the periparturient dairy cow.”
Choline is also known to be involved in the synthesis of carnitine, cell membrane phospholipids, and the neurotransmitter acetylcholine. It is a major source for methyl groups via its metabolite trimethylglycine (betaine) that participates in the S-adenosylmethionine synthesis pathways. Lastly, choline has also been shown to specifically aid with memory, and to support the maintenance of a healthy nervous system. Food sources of choline include peanuts, soybeans, wheat, chicken, fish, beef, cauliflower, eggs, and lettuce.
Cyanocobalamin (Vitamin B-12) – This form of B-12 vitamin is used in our Lipo-B injection and plays a significant role in the replication of DNA, the normal functioning of the nervous system, and the formation of blood cells. The vitamin B-12 injection has been shown to provide these key benefits: boosts energy and overall metabolic rate; assists in the burning of stored body fat; detoxifies the body; increases red blood cell production; maintains a healthy liver; helps regulate sleep, mood, appetite and energy; works synergistically with other nutrients to improve health; and slows aging.
Vitamin B-12 is frequently used in combination with other B vitamins in a vitamin B-complex formulation. Important in DNA synthesis, vitamin B-12 is bound to the protein in food, and is released by stomach acids during digestion. Once released, B-12 combines with a substance called intrinsic factor (IF) before it is absorbed into the bloodstream. Essentially water-soluble this vitamin is commonly found in a variety of foods such as fish, shellfish, meat, eggs, and dairy products. Read more about Vitamin B-12 Injections.
L-Carnitine – Carnitine is an amino acid which is required for the transport and breakdown of body fat for the generation of metabolic energy. Studies show that oral L-Carnitine supplementation can decrease fat mass, preserve muscle during exercise, and reduce muscle fatigue. Further research over the last decade has shed new light on the importance of L-carnitine as a regulator of skeletal muscle fuel selection, which means it is needed to determine whether muscle tissue utilizes carbohydrates or fat for energy. When taken orally, L-Carnitine requires a high dose to promote fat tissue breakdown. This is because only a fraction of carnitine is absorbed during oral digestion. When administered by injection, nutrients like L-Carnitine are completely absorbed by the body.
Lipo-B Injection is commonly prescribed for:
Help stimulate the breakdown of lipids (fat) during metabolism
To reduce the accumulation of excess fat in the liver and other tissues
Ingredients and dosage strengths of Lipo-B injection include:
10 mL vial. Methionine 25 mg/mL, Inositol 50 mg/mL, Choline Chloride 50 mg/mL, Cyanocobalamin 1 mg/mL30 mL vial. Methionine 25 mg/mL, Inositol 50 mg/mL, Choline Chloride 50 mg/mL, Cyanocobalamin 1 mg/mL
The dosage form available for Lipo-B is Injection Solution. Empower Pharmacy’s injection solutions are compounded under the stringent USP 797 guidelines for sterile compounding, and sterility, endotoxin, potency and pH testing is performed on every batch. Our quality-assurance process ensures the consistency and uniformity of every solution for injection we dispense.